Restriction on self-renewing asymmetric division is coupled to terminal asymmetric division in the Drosophila CNS.
Neuronal precursor cells undergo self-renewing and non-self-renewing asymmetric divisions to generate a large number of neurons of distinct identities.In Drosophila, Collagen Protein primary precursor neuroblasts undergo a varying number of self-renewing asymmetric divisions, with one known exception, the MP2 lineage, which undergoes just one termi